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Protein Structural Analysis & Design Laboratory

Michigan State University
502C Biochemistry Building
E. Lansing, MI 48824-1319

Ph: (517) 353-8745  Fax: (517) 353-9334

Model for how monoclonal antibody 3D6 (yellow and green tubes) can recognize a helical peptide (blue) in Brugia malayi asparaginyl-tRNA synthetase and neutralize its enzymatic activity by occluding the active site.  See M. A. Kron et al. (2008), under Publications.
Welcome to the PSA Laboratory

About Our Work

Through structural modeling and analysis of proteins and the small organic molecules they bind, our aim is to understand how 3-dimensional atomic structures encode the preference to bind a specific small molecule partner. This chemistry puzzle is made more interesting by the contributions of molecular flexibility and solvation during binding. A related problem we tackle is to discover the natural binding partner(s) for protein sequences and modeled 3-dimensional structures by using pattern recognition of shared binding site features relative to proteins of well-defined function. Our lab both deduces and applies knowledge about binding specificity through the development of hypothesis-driven molecular screening, molecular alignment, flexibility modeling, and docking software. Our biological applications address pressing environmental and medical challenges, in collaboration with physiologists, behavioral scientists, chemists, and clinicians.

Leslie Kuhn, Lab Director

Interaction between sea lamprey olfactory receptor 1 and 3-ketopetromyzonol sulfate pheromone (white tubes).