Protein Structural Analysis & Design Laboratory
Michigan State University
502C Biochemistry Building
E. Lansing, MI 48824-1319
Ph: (517) 353-8745 Fax: (517) 353-9334
About Our Work
Through structural modeling and analysis of proteins and the small organic molecules they bind, our aim is to understand how 3-dimensional atomic structures encode the preference to bind a specific small molecule partner. This chemistry puzzle is made more interesting by the contributions of molecular flexibility and solvation during binding. A related problem we tackle is to discover the natural binding partner(s) for protein sequences and modeled 3-dimensional structures by using pattern recognition of shared binding site features relative to proteins of well-defined function. Our lab both deduces and applies knowledge about binding specificity through the development of hypothesis-driven molecular screening, molecular alignment, flexibility modeling, and docking software. Our biological applications address pressing environmental and medical challenges, in collaboration with physiologists, behavioral scientists, chemists, and clinicians.
Leslie Kuhn, Lab Director