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SLIDE Information Page

Protein Structural Analysis Laboratory
Department of Biochemistry & Molecular Biology
Michigan State University

Email: kuhnlab@msu.edu

Model for how monoclonal antibody 3D6 (yellow and green tubes) can recognize a helical peptide (blue) in Brugia malayi asparaginyl-tRNA synthetase and neutralize its enzymatic activity by occluding the active site.  See M. A. Kron et al. (2008), under Publications.
Protein Structural Analysis Laboratory Software

SLIDE

Introduction

Discovery of a novel nM inhibitor of thrombin using SLIDE (see Zavodszky et al, 2009 under Publications).

MSU SLIDE ('Screening for Ligands by Induced-fit Docking, Efficiently') represents a general approach to organic and peptidyl database screening. It can handle large binding-site templates and uses multi-stage indexing to identify feasible subsets of template points for ligand docking. An optimization approach based on mean-field theory is applied to model induced-fit complementarity, balancing flexibility between the ligand and the protein side chains. SLIDE can screen 100,000 compounds within a few days and returns a ranked list of sterically feasible ligand candidates, ranked by complementarity to the protein's binding site.

SLIDE is available for licensing to academic and commercial researchers. Please see the section on License Agreements for more information.

Publications related to SLIDE include the following:

Please note, you will need Adobe Acrobat Reader to view the pdf files listed above. You can download a free copy of Acrobat Reader from here.

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User Manual

SLIDE user manuals, quick guides, and flyers:

Please note, you will need Adobe Acrobat Reader to view these pdf files. You can download a free copy of Acrobat Reader from here.

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SLIDE Tutorial

A detailed SLIDE Tutorial is now available for download, which covers v. 3.3.5 as well as the newly released version 3.4.

Please see the steps in the SLIDE Quick Guide for a quick overview and examples of running SLIDE. Email kuhnlab@msu.edu, with any further questions.

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License Agreements

SLIDE is now available for licensing to academic and commercial researchers. To arrange a license or for scientific inquiries, please contact:

Leslie Kuhn
502C Biochemistry Building
MSU, East Lansing, MI 48824

Telephone: (517) 353-8745
E-mail: kuhnlab@msu.edu

Academic License Agreement

Commercial License Agreement


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Release Notes

Version 3.4 of the SLIDE Release Notes are now available for download below. For those users of previous versions of SLIDE who wish to upgrade, please email the authors at kuhnlab@msu.edu.


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Contact Information


Scientific Support and Licensing Information

Dr. Leslie Kuhn
Protein Structural Analysis and Design Lab
502C Biochemistry
Michigan State University
East Lansing, MI 48823

Tel: 517-355-8745
Fax: 517-353-9334
Email: kuhnlab@msu.edu

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